Advancing Glaucoma Diagnostics with Functional and Structural OCT Imaging

In order to determine the most trustworthy reference for normalizing Nerve Fiber Layer (NFL) reflectance in Spectral Domain Optical Coherence Tomography (OCT), a crucial indicator for early glaucoma identification, this work does a thorough examination. The study examines various normalization metrics using two different cohorts: a clinical dataset (FSOCT) comprising normal, preperimetric glaucoma, and perimetric glaucoma eyes, and a controlled experiment using Neutral Density Filters (NDF) to imitate signal attenuation.